🔶 I’m happy to share that our recent work, ‘Are the Analgesic Effects of Morphine Added to Transversus Abdominis Plane Block Systemic or Regional? A Randomized Clinical Trial‘, has been published in 𝘗𝘢𝘪𝘯 𝘙𝘦𝘴𝘦𝘢𝘳𝘤𝘩 𝘢𝘯𝘥 𝘔𝘢𝘯𝘢𝘨𝘦𝘮𝘦𝘯𝘵, under the design and editorial leadership of Dr. Meryem Onay
We believe this study is valuable, especially in terms of its structure and technical quality.
If you’re interested in regional or obstetric anaesthesia, please take a moment to read it. (Open Access)
📄 https://doi.org/10.1155/prm/9187270
I’d be more than happy to hear your thoughts — any comments or critiques are very welcome.
Thanks for your time and support!
𝗔𝗯𝘀𝘁𝗿𝗮𝗰𝘁:
𝗕𝗮𝗰𝗸𝗴𝗿𝗼𝘂𝗻𝗱: This study was designed to compare the effectiveness of the transversus abdominis plane (TAP) block with the addition of morphine to bupivacaine and the TAP block with bupivacaine plus intramuscular (IM) morphine. The aim of the study was to evaluate the effect of morphine administered with the TAP block on postoperative opioid consumption and pain scores and, secondarily, to determine whether the effect was systemic or local.
𝗠𝗲𝘁𝗵𝗼𝗱𝘀: This prospective, double-blind, randomized controlled trial included 52 patients. In the IM group, morphine at a dose of 0.1 mg/kg based on ideal body weight (IBW) was administered IM. In addition, a bilateral TAP block was performed under ultrasound guidance using a total of 40 mL of 0.25% bupivacaine, with 20 mL injected on each side. In the TAP group, an ultrasound-guided TAP block, including a total of 40 mL of 0.25% bupivacaine and 0.1 mg/kg morphine according to the IBW of patients, was administered bilaterally.
𝗥𝗲𝘀𝘂𝗹𝘁𝘀: Total morphine consumption 24 h was 19.08 + 11.35 in the IM group and 11.81 + 7.02 in the TAP group, with an estimated difference in means of 7.2 (95% CI: 2.0, 12.5; p = 0.008). The morphine consumption after 6, 12, and 24 h was lower in the TAP group than in the IM group (p = 0.033, p = 0.003, and p = 0.008, respectively). The VAS scores at rest and during movement did not differ between the two groups. The total 24-h ondansetron consumption was higher in the IM group (p = 0.046). The postoperative heart rates, blood pressure, and peripheral oxygen saturation at 0, 1, 6, 12, and 24 h did not differ significantly between the groups.
𝗖𝗼𝗻𝗰𝗹𝘂𝘀𝗶𝗼𝗻𝘀: The addition of morphine to the TAP block may be an effective method for postoperative analgesia in gynaecologic surgery and may not increase systemic side effects, due to the possible local effects of morphine administered interfacial.